Objective. To investigate the therapeutic potential and efficacy of Shinbaro, an herbal medication for inflammatory diseases and\nbone disorders, as a preventive treatment of migraine. Methods. In this prospective, interventional, single-arm, pre-post study,\n37 migraine patients took 600mg bid of Shinbaro for 12 weeks. At 4-week intervals, the migraine frequency and the rescue\nmedications frequency weremeasured fromeach patientâ??s headache diary. Themodified Migraine Disability Assessment (MIDAS)\nquestionnaires to assessmigraine associated disabilities were also completed at each visit.The serumcalcitonin gene-relatedpeptide\n(CGRP) concentrations before and after 12 weeks of Shinbaro administration were compared. .....................
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